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In NSCLC, specific genetic alterations in the EGFR gene, most notably exon 19 deletions and the L858R point mutation in exon 21, lead to constitutive activation of the receptor tyrosine kinase (RTK) (49,50) (Fig

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Although their activity on a single target may be lower compared to single-target drugs, the synergistic effects of multi-target modulation result in a total effect greater than the sum of the individual effects, leading to better efficacy and fewer adverse reactions

Upon exposure to 808 nm NIR laser irradiation, the photosensitizer ICG generates a substantial amount of reactive ROS, inhibiting the excessive proliferation of P