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This lack of specificity poses a major obstacle to clinical translation, as s widespread distribution can damage healthy tissues dependent on normal iron metabolism and redox homeostasis

In contrast, SET7 attenuated the inhibitory effect of OTUB1 (OTU domain-containing ubiquitin aldehyde-binding protein 1) on cystine starvation/erastin-induced ferroptosis by directly interacting with non-histone OTUB1 to catalyze its methylation on lysine 122

Ahern, C

Phosphatidylethanolamine is converted to phosphatidylcholine by phosphatidylethanolamine N-methyltransferase

10.1124/mol.65.6.1364 113 VercellinoI.SazanovL

Ding R, Darland DC, Parmacek MS, D'Amore PA