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They exert neuroprotective actions and their loss during aging and natural or surgical menopause is associated with mitochondrial dysfunction, neuroinflammation, synaptic decline, cognitive impairment and increased risk of age-related disorders

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394 Lesinurad is metabolized and eliminated predominantly by the liver (75%) and to a lesser extent by the kidneys (25%), with a half-life of approximately 9 to 10 h

10.1007/s12035-018-0986-z 62 JahanS.SinghS.SrivastavaA.KumarV.KumarD.PandeyA.et al (2018b)

4.3 Liver and kidney surgeries (ischemiareperfusion injury and immune modulation) 4.3.1 Liver surgery/transplantation The liver is rich in macrophages (Kupffer cells) and is often subject to IR during inflow occlusion in resection or during transplant graft implantation

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