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Coastal sediments often serve as the depository for contaminants from various sources, such as riverine inputs, atmospheric deposition, and direct industrial discharges

Zhou et al., 2007a

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BOX1: Complexity of genetic alterations and metabolism in PDAC In addition to the most frequent oncogenic somatic mutation KRAS , a high percentage of patients carry inactivating somatic mutations in the tumor suppressors cyclin-dependent kinase inhibitor 2 A ( CDKN2A ), tumor protein 53 ( TP53 ), and SMAD family member 4 ( SMAD4 ) [113,114,115], reinforcing their roles during PanIN-to-PDAC [116]

Smoking rapidly uses up glutathione in the lungs and throughout the body as it tries to neutralize the multitude of free radicals in cigarette smoke