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The first one was taken at base line, while the second was taken from the nearest point to the first one after stoppage of treatment (3 months after start of treatment)

We identified five major FG-binding pockets on the convex surface of importin , formed at the interface between HEAT repeats H4H6 (pocket 1), H6H7 (pocket 2), H7H8 (pocket 3), H9H10 (pocket 4), and H16H17 (pocket 5) (Fig