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69 LimK.YangS.KimS.JooJ

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doi: 10.1161/ATVBAHA.121.316021 121 HeSTianRZhangXYaoQChenQLiuBet al

During excessive ER-phagy, approximately fivefold more autophagic vacuoles are produced than that which are produced in cells under physiological conditions, and twice as many as those in the stressed state [39]

Numerous preclinical reports have highlighted the ability of curcumin to restore reduced GSH levels and the activities of GSH-related antioxidant enzymes in the myocardium after exposure to cardiotoxic factors, for example, DOX, I/R, diabetes, hyperthyroid conditions, and copper sulfate [184,185,186,187,188]