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10.1002/stem.2020 132 LeeF

In the last decades, IGF-1 has been implicated in many physiological actions, among others: tissue growth and development, proliferative, lipid metabolism, pro-survival/anti-aging, anti-inflammatory, anabolic, and antioxidant with neuro- and hepatoprotective properties [105116]

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For PT-141, the evidence is strongest: its FDA-approved under the brand name Vyleesi for hypoactive sexual desire disorder in women, and it has meaningful off-label use in men for erectile and libido issues that dont respond to PDE5 inhibitors