Figure 3C), and HOMA-IR ( = 0.046, = 0.060
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Feel depressed and exhausted even though you eat well and sleep enough
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These divergent effects on ARE-bindings were reflected in the expression of AR-dependent genes that were impacted by SUMOylation: genes activated by AR negatively regulate cell proliferation, and those repressed by AR are involved in pattern formation by WNT, TGF-B, and FGF signaling [74]
