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Oncolytic viruses Oncolytic viruses (OVs) represent a promising therapeutic strategy for GBM, leveraging their ability to selectively infect and lyse rapidly proliferating tumor cells while transforming the immunosuppressive TME into an immune-responsive state

Considering that the human APOE isoform further regulates A clearance efficiency, and that sex and age modulate APOE-related AD risk via hormonal and aging factors (Valencia-Olvera et al., 2023)