DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE cyclopropene 333 SMILES BrCCCCCCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

333 SMILES BrCCCCCCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

82 SMILES: Cl

5-TAMRA cadaverine is the purified single isomer of 5(6)-TAMRA cadaverine mixture

Product Name: 5-FAM lysine Synonyms: Fluorescein-5- carboxamide lysine CAS Number: N/A Molecular Formula: C27H24N2O8 Molecular Weight: 504

39 SMILES CC1=CN=C(NC(=O)CC2=COC3=CC4=C(CCC4)C=C23)S1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE cyclopropene 333 SMILES BrCCCCCCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further