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Considering the paramount importance of oxLDL in the pathogenesis of atherosclerosis, it is reasonable to evaluate the role of antioxidants in the treatment of the disease as adjuvant strategies to lipid-lowering or anti-inflammatory therapies designed to reduce the risk of cardiovascular disease (230)

We previously reported that reduced levels of activated hepatocyte growth factor and the c-Met receptor tyrosine kinaseboth of which are vital for maintaining cellular redox balancecombined with increased expression of GJ proteins in hepsin-deficient mice

Conversely, another subset of CD8 + T cells can augment vascular inflammation through the production of IFN and TNF, and worsen plaque instability by killing VSMCs and VECs 2,4

A framework for examining how diet impacts tumour metabolism

doi: 10.1016/j.freeradbiomed.2014.11.017 52 ShigenagaT.YamauchiN.FunamotoY.ShigyoM

29 In addition to survival outcomes, IDH mutations define a distinct epigenetic subclass, G-CIMP, that is linked to a better prognosis