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Theorien, Methoden, Anwendungen, Wiesbaden: VS-Verlag, 279-296

The initiation of the process is catalyzed by the intracellular iron pool, which reacts with hydrogen peroxide and superoxide to produce oxygen-centered radicals

To test whether low oxygen tension experienced by retinal cells can stimulate mitophagy, we injected Naive mice or those exposed to OHT (OHT) with pimonidazole, a compound that creates covalent adducts in cells that experience a partial pressure of oxygen lower than 10 mmHg (hypoxia)

[DOI] [PMC free article] [PubMed] [Google Scholar] 161.Bontemps F, Van Den Berghe G

78 JanssensN.LesageA

JAMA (2014) 312(3):24958