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Front Mol Biosci 9:858142

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doi: 10.1016/S0140-6736(98)90086-1 2

Proton magnetic resonance spectroscopy (1H-MRS) has detected reduced GABA concentrations in the frontal and motor cortices, cerebellum, anterior cingulate cortex, and sensorimotor regions of ASD patients, along with decreased ratios of GABA/glutamate, N-acetylaspartate/creatine, GABA/creatine, and glutamate/creatine