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Development of engineered probiotics with tailored functional properties and their application in food science

Repeated administration via nasal or intravenous routes remains safe, which is critical for managing chronic diseases such as AD [53]

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Notably, supplementation with ferrostatin-1 or trolox, both of which are radical-trapping antioxidants and potent inhibitors of ferroptosis, rescued survival but not proliferation under cystine-free conditions (Extended Data Fig

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However, in Lewy body disease with comorbid AD, Lewy-related pathology in the amygdala is found from an early stage and even in the absence of Lewy-related pathology in the brainstem [192, 193, 334]