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For grass-fed cattle, antibiotics are typically not given, which is very different form the consistent and common use of antibiotics on feed-lot, grain-fed cows

The Smad family of proteins are intracellular signalling proteins that are directly involved in TGF- signalling, as well as members of several protein families such as BMP, which regulate osteoblast and osteoclast functions and play key regulatory roles in bone remodeling [55, 56]