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however, several challenges still need to be addressed

No human efficacy trial has met the evidentiary bar for regulatory approval

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tested the effects of a multispecies probiotic on innate immune function, bacterial translocation, and intestinal permeability in a randomized placebo-controlled clinical trial in patients with cirrhosis and demonstrated an increase in serum neopterin levels and production of ROS by neutrophils, and some improvement in liver function in patients treated with probiotics