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Administration less frequent than twice weekly likely allows complete dissipation of synaptic changes between doses, preventing the cumulative structural modifications that constitute Dihexas therapeutic mechanism

PMID: 5 BozhedomovVALipatovaNARokhlikovIMAlexeevRAUshakovaIVSukhikhGT

Grant, Daniel J

Stimulation of mitogenesis and glucose transport by 1-monooleoylglycerol in Swiss 3T3 fibroblasts

Thus, concern remains for higher on-target off-tumor toxicity with greater CAR-T cell expansion, as seen in a patient treated with ERBB2-CAR-T therapy who experienced fatal cytokine release syndrome from on-target, off-tumor effect [165]