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The disadvantage is that lower doses become harder to measure accurately

doi: 10.1136/jcp.55.10.754

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Table 3 identified the phenol component (Total Polyphenols and Total Flavonoids), the cocoa bean variety (Criollo, Forastero, Trinitario, and Nacional), and the measurements for cocoa mucilage (expressed in mg GAE/100 mL) and cocoa bean shell (expressed in mg GAE/100 g DW) for each sample

Those that develop acute liver failure can still recover spontaneously, but may require transplantation if poor prognostic signs such as encephalopathy or coagulopathy is present (see King's College Criteria)