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Developing TME-responsive targeted delivery systems and combining ferroptosis inducers with immune checkpoint inhibitors or CAF inhibitors can enhance therapeutic efficacy and reduce toxicity ( In summary, ferroptosis holds great potential for the treatment of digestive tract tumors, but its clinical translation relies on in-depth deciphering of the interaction mechanisms between TME, immunity, and ferroptosis

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doi: 10.1007/s000400050017 89 VonaeschP.AndersonM.SansonettiP

Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid- peptide