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DPI has also been employed in numerous studies as a ROS inhibitor due to its demonstrated efficacy in reducing superoxide production during reverse electron transport (20, 21)

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Additionally, a 2025 retrospective study on chronic knee pain showed that 14 out of 16 patients reported significant relief lasting 612 months, and a 2024 pilot study on interstitial cystitis achieved symptom resolution in 10 out of 12 subjects