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It improves cardiac function and ultrastructure, and inhibits MF development in DOX-induced CHF rats by upregulating extracellular matrix-metalloproteinase inhibitor (TIMP) expression (76) (Figure 2)

It is important to mention that studies promoting ferroptosis by targeting iron metabolism and lipid peroxide formation are clearly lacking

Moreover, EVs may be transferred from drug-resistant cancer cell to drug-sensitive counterparts and thus plays a role in the horizontal transfer of drug resistance in cancer cells by delivering specialized cargo which includes drug resistance-related proteins (P-gp, ABCG2, ABCA3, etc.), nucleic acids (mt DNA, mRNAs, miRNAs), onco-metabolites, antiapoptotic proteins [22, 23]

doi: 10.1517/17425255.2013.796929

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Protective role of quercetin against cisplatin-induced hair cell damage in zebrafish embryos