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Small-molecule TKIs include imatinib, dasatinib, nilotinib, ponatinib, bosutinib, sorafenib, sunitinib, pazopanib, axitinib, vandetanib, dovitinib, vemurafenib, dabrafenib, and ruxolitinib

First, the complex appears to act as a copper transporter, delivering ionic copper to cutaneous cells where it may activate copper-dependent enzymes involved in extracellular-matrix remodeling and angiogenesis

Boosting delivery of rare disease therapies: the IRDiRC Orphan Drug Development Guidebook

Third, BPC-157 increases tendon fibroblast outgrowth and migration in vitro under stress conditions, suggesting a direct cellular effect on the repair cell population

It directly impacts both measured outcomes and dropout rates due to nausea

The clinical evidence base for these agents, both individually and in combination, is still emerging