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Restoring mitophagy by injection of Tat-Beclin1 attenuated mitochondrial dysfunction, decreased lipid accumulation and protected against diastolic dysfunction [90]

Mechanism of Action Ethosuximide has an important effect on Ca 2+ currents, reducing the low-threshold (T-type) current

20 , e3001437 (2022)

In addition, the pro-oxidant/antioxidant effects of polyphenols and vitamins are context-dependent and moderate doses may be cardioprotective while supraphysiologic levels negatively affect the oxidative state or disrupt ROS-mediated signalling that is important for chemotherapy-induced killing of tumour cells (218)

MOTS-c translocates to the nucleus during metabolic stress to regulate antioxidant and glucose metabolism genes via AMPK activation [4]

GSH levels decreased in both treatment groups after a 1-month washout period but remained significantly higher than baseline in the high-dose group