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In detail, inhibition of HDAC by sodium butyrate induces acetylation of histone H3 (at Lys14) and histone H4 (at Lys16), resulting in the activation of the transcriptional regulation of CYP1A1, an important metabolic enzyme, in human colon carcinoma HCT116 cells [66]

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271 An in vitro experiment has shown that costunolide treatment can induce HIF-1 degradation, leading to reduced glycolysis in Th17 cells and decreased Th17 cell differentiation

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Recently, our group studied the effect of low dose sodium selenite supplementation (multiple intraperitoneal injection of 4 g/kg body weight) on the 30-day survival of mice against the lethal dose (8 Gy) of WBI with -rays (Table 2) [50]