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10.1038/nrneurol.2017.13 Nat Rev Neurol

Age reprogramming and epigenetic rejuvenation

Activated phosphoinositide 3-kinase delta (PI3K) syndrome (APDS) is an inborn error of immunity with clinical manifestations including infections, lymphoproliferation, autoimmunity, enteropathy, bronchiectasis, increased risk of lymphoma, and early mortality