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Statistical analysis Data are expressed as mean standard deviation, unless indicated otherwise

Cho S, Lee YH, Park H et al (2001) Glutathione S-transferase mu modulates the stress-activated signals by suppressing apoptosis signal-regulating kinase 1

These shared proinflammatory lipid signatures point to common pathogenic mechanisms driving multiorgan dysfunction in metabolic-pulmonary comorbidities, offering a mechanistic framework for understanding the shared pathophysiology between DM and COPD (Caughey et al., 2013

When there is a disruption or blockage in the blood vessels supplying the brain, it can lead to various vascular disorders like stroke and vascular dementia (10)

Effect of the serum samples on the endothelial cells The endothelial monolayers in 48-well culture plates were exposed for 24 h to the standard culture medium supplemented with the serum sample (20%v/v)

In high-glucose environments, the retina, a tissue with significant oxygen demand, is especially susceptible to injury