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To analyze the enrichment of predicted shared tier-1 targets across all datasets among cellular metabolic pathways, we used the human metabolic model Recon2.2 to identify genes associated with each metabolic subsystem annotated in the model

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Visceral obesity, metabolic syndrome, insulin resistance and cancer

Similarly, genistein, a soy-derived isoflavone, was found to reverse the hypermethylation of TSGs via a direct inhibition of DNA methyltransferase, suggesting these natural extracts could contribute to the chemoprevention of ESCC [145]