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Calculation of unfolded energy for pAcF To assess the impact of pAcF on protein stability, the Rosetta Unfolded State Energy Calculator protocol was employed

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In addition, the ROS produced by ATMs first affect their recruitment and polarization, especially in cases such as diabetes, ROS induces ATMs to polarize towards M1 and the release of inflammatory factors (145, 146)

and increased levels of Bax, caspase-3 and caspase-9, confirming that -hederin induces apoptosis via the mitochondrial pathway (Wang et al

Tumor necrosis factor (TNF- ), interferon (IFN- ), and interleukins such as IL-6 and IL-1 have been reported to cause the failure of the BBB