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The guide cannula measured 2.5 cm in overall length and was prepared with a heat bulge placed 2.5 mm from its beveled tip, thus acting as a stop to control the depth of penetration

Hypoxia inhibits PHD, which stabilizes HIF- and promotes its migration to the nucleus where it dimers with the subunit and binds to the promoters or enhancers through the hypoxia response elements (HRE) to initiate gene transcription (19, 20)