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Oxidative stress mediates collateral sensitivity to tamoxifen Earlier reports have shown that heightened P-gp ATPase leads to selective decrease in cellular ATP level and a rise in reactive oxygen species (ROS), likely due to higher electron leak from mETC though enhanced oxidative phosphorylation [15, 16]

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Furthermore, metformin treatment significantly decreased IL-1 level but had no significant effect on IL-6 in the plasma of Nrf2 KO mice under OA condition (Fig