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Keywords : Nanoparticles, Insulin, Insulin-like growth factor, Bone regeneration, Angiogenesis, Osteogenesis According to the world health organization, over 500,000 bone grafting procedures with a cost greater than $2.5 billion are performed annually in the United States [1]

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By combining Reverse Transcriptase inhibitors plus protease inhibitors, synergism was obtained and the amounts of viral particles in the plasma plummeted, while the speed of the developing mutant resistant viral strains was slowed, compared to using only one type of inhibitor

Hickey AJ, Chai CC, Choong SY, et al

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Circulation 123 , 1322 (2011)