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Consequently, stabilized Nrf2 is translocated to the nucleus, where it forms heterodimers with the essential cofactors small Maf (sMaf) proteins and binds to the antioxidant response element (ARE)

In addition, reagents for detecting the expression of AIF1 are well known

Semaglutide binds GLP-1 receptors, glutathione functions as an intracellular antioxidant

Several issues must be carefully considered during implementation: the patients cardiopulmonary reserve function threshold (Neder, 2023), fluctuations in disease progression, and long-term adherence to the intervention