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doi: 10.1186/s11689-017-9207-8 153 ChadwickWAngulo-HerreraICogramPDeaconRJMMasonDJBrownDet al

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In the NVU, endothelial cells are primarily responsible for the barrier functionality, with TJs between adjacent cells forming capillary walls in the CNS 9

At the same time 32% of those studied experienced adverse events, including liver dysfunction and one case of anaphylaxis (Alzahrani et al., Cureus 2025, PMID 40013212)