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Description

PMID 10569624

(1986) Dual effects of growth hormone (GH)-releasing hormone infusion in normal men: somatotroph desensitization and increase in releasable GH

This modification in the protein structure ensures a reduced binding affinity of IGF-1 LR3 for IGF-binding proteins in comparison to IGF-1 [6]

The modifications in the latter work primarily to increase the half-life of the peptide from 5-10 mins for sermorelin, to around 30 mins [13, 14]

Ipamorelin is a synthetic pentapeptide belonging to the group of ghrelin mimetics, acting as a selective agonist of the GHS-R1a receptor (Growth Hormone Secretagogue Receptor)