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Long-term management strategies Injection site reactions are not a one-time problem for many users

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*Correspondence: Vishwanath Venketaraman, [email protected] This article was submitted to Clinical Microbiology, a section of the journal Frontiers in Cellular and Infection Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The individual AIM SRCR binding domains have specialisations in their interaction with IgM, including an unusual cysteine in SRCR2 which makes a disulfide linkage to Fc, and a metal ion binding site on SRCR3 that is present in other SRCR-SF domains