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Within Cluster I there are amino acid metabolism systems such as valine, leucine and isoleucine degradation, D-alanine metabolism, lysine biosynthesis, cysteine and methionine metabolism, alanine, aspartate, and glutamate metabolism

We compare traditional systemic routes, including oral and intravenous, with intranasal administration, highlighting their respective advantages and limitations for CNS delivery

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Park et al., 2020)