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Chronic administration of high doses of oral levocarnitine in patients with severely compromised renal function or in ESRD patients on dialysis may result in accumulation of the potentially toxic metabolites, trimethylamine (TMA) and trimethylamine-N-oxide (TMAO), since these metabolites are normally excreted in the urine Side Effect Generally Levocarnitine is well tolerated

Moreover, LC administration did not influence bench press results

Bibcode:1998BBRC..250..506V

Differences in metabolic profiles at baseline and post-treatment were noted between participants who remitted (HRSD 17 7) and those who gained no meaningful benefits ( 14 on HRSD 17 were eligible for inclusion in the trial

(2014) PLoS One | doi:10.1371/journal.pone.0084589 Stephens FB, Marimuthu K, Cheng Y, et al.: Vegetarians have a reduced skeletal muscle carnitine transport capacity

We can discuss limitations