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Specifically, hASC-EVs activate the PI3K/Akt pathway and promote Nrf2 nuclear translocation via p62-mediated KEAP1 degradation, thereby enhancing antioxidant defense [153]

The reality check and this is the most cautionary one in the article: IGF-1 LR3 carries a serious risk profile

Dysregulation of stathmin, a microtubule-destabilizing protein, and up-regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral

FIGURE 1 Given the scope of this review, we will summarize insulin actions on non-renal target organs, but detailed information is available in recent reviews (Gancheva et al., 2018