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Inhibitory kappa B kinase beta (IKK), known as IKK2, is a key regulatory kinase responsible for the activation of NF-B through its phosphorylation at Ser177 and Ser181 to promote the phosphorylation of inhibitors of kappa B (IBs), triggering their ubiquitination and degradation to active the nuclear factor kappa-B (NF-B) cascade

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