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Histidine tagging is by no means the only affinity tagging option

Semaglutide Component Properties Complete Specifications: Classification: GLP-1 receptor agonist Molecular Weight: 4,113 Da Molecular Formula: CHNO Structural Basis: Modified human GLP-1(7-37) with Aib8 and C18 fatty acid at K26 Key Modifications: Aminoisobutyric acid (Aib) at position 8, C18 fatty diacid at K26, linker modifications Primary Target: GLP-1 receptors (class B GPCR) Mechanism: GLP-1 receptor agonism with 94% albumin binding Plasma Half-Life: ~165 hours (~7 days), enabling once-weekly research administration CAS Number: 910463-68-2 Appearance: White to off-white lyophilized powder The semaglutide component provides long-acting GLP-1 receptor activation research capabilities

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Pattappa, G

It will nevertheless be understood that no limitation of the scope of the invention is thereby intended, and alterations and modifications in the illustrated invention, and further applications of the principles of the invention as illustrated therein are herein contemplated as would normally occur to one skilled in the art to which the invention relates