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Those patients that have complications that have been shown to be ameliorated by GLP-1-based drugs, and I would say secondary prevention of cardio, of heart attacks for semaglutide

10.1007/s40618-016-0523-8 J Endocrinol Invest

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Aylett, C

Furthermore, research has shown that fasting, CR, and caloric restriction mimetics (CRMs) can promote T-cell-mediated tumor cytotoxicity, alter NK cell function, and potentially trigger immunogenic cell death, thereby stimulating cancer immunosurveillance pathways

However, tablets are limited by their slow onset of action, potential swallowing difficulties, and risk of gastric irritation