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Even more alarming are reports of HCC from NAFLD that occurred in the absence of cirrhosis[4]

It is currently being investigated in phase 3 trials, and results from a phase 2 trial published in the New England Journal of Medicine are show great promise

2024 Jul 15];103

The data of gene expression profiling have been uploaded to the NCBI Gene Expression Omnibus under accession number GSE152537

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However, excess ROS induces inflammatory cell infiltration and macrophage polarization through mitochondrial homeostasis disruption and production of pro-inflammatory factors, forming a vicious cycle of central nerve inflammation and ROS production, further aggravating inflammation and the formation of glial cell scar