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First-in-human phase 1 study of the antibody-drug conjugate (ADC) SAR408701 in advanced solid tumors: dose-expansion cohort of patients (pts) with non-squamous non-small cell lung cancer (NSQ NSCLC)

10.1016/j.jnutbio.2016.10.005 201 NicolescuA.BabotM.BarrosL.RocchettiG.LuciniL.TanaseC.et al (2023)

Thats vitamin B12

In our experiments in vitro [104], followed by the sulfenylation of Cys111 in metal-bound SOD1 with H 2 O 2 , dissociation of the bound metal ions from the protein was found to allow another free Cys residue (Cys6) to attack the sulfenylated Cys111

The presence of comorbidities can complicate the clinical picture and may influence the neurobiological mechanisms underlying depression in the context of chronic alcohol use

This enables them to carry more hemoglobin (and therefore more oxygen) and become highly flexible in shape