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Experimental models were used to investigate the effects of these phytochemicals, many of which exhibited multiple mechanisms beneficial for managing HUA

doi: 10.1371/journal.pone.0102438 67 MelzerCvon der OheJLehnertHUngefrorenHHassR

This finding contrasts with observations in transformed cells where Arg deprivation more robustly induces ribosome pausing and GCN2 activation compared with Leu starvation (Darnell et al, 2018)