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doi: 10.3389/fncel.2017.00149 14

Iron is deposited in the brain cells of AD patients, and excessive iron will exacerbate oxidative damage and cognitive deficits (Bao et al., 2021)

Emma F, Nesterova G, Langman C, Labbe A, Cherqui S, Goodyer P, Janssen MC, Greco M, Topaloglu R, Elenberg E, Dohil R, Trauner D, Antignac C, Cochat P, Kaskel F, Servais A, Wuhl E, Niaudet P, Vant Hoff W, Gahl W, Levtchenko E (2014) Nephropathic cystinosis: an international consensus document

ME1 is a mitochondrial enzyme that metabolizes malate to pyruvate to generate NADPH

This is essentially an acknowledgment of prolotherapys potential: SI joint pain in EDS is notoriously hard to treat (regular surgery is rarely a good option), so a successful prolotherapy outcome represents a valuable solution