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The study was conducted in accordance with HIPAA and HITECH requirements, which expand upon the ethical principles detailed in the 1964 Declaration of Helsinki

Dietary pectin shortens the biologic half-life of vitamin B-12 in rats by increasing fecal and urinary losses

Patients in STEP 1 were desirous of weight loss as a reason for study participation and received structured lifestyle intervention (which included a 500 kcal per day diet with 150 min per week of physical activity)

Experimental studies suggest that DSIP influences the release of stress-related hormones such as adrenocorticotropic hormone and cortisol analogs in animal systems, indicating a role in feedback regulation of neuroendocrine stress pathways [4]

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