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For the main studies, female C57BL/6-Apoe tm1 ApoE -/- mice were purchased from Taconic (Ejby, Denmark) at eight weeks of age and allowed two weeks of acclimation before the experimental procedure

Activation of the NLRP3 inflammasome represents a key step in IL-1 production during HIRI, further promoting neutrophil recruitment and amplification of the inflammatory response (45)

Postnatal development of the circadian rhythmicity of human pineal melatonin synthesis and secretion (systematic review)

Because gastric banding does not surgically remove or bypass the stomach or small intestine, the anatomical pathway for B12 absorption remains largely intact after LAGB

Therefore, these limitations made it necessary the use of polymeric NPs as more effective THA delivery carriers compared with free drugs, including Methoxypoly (ethylene glycol)-Polycaprolactone (mPEG-PCL) NPs in rat brain (Sathesh Kumar and Felix Joe, 2017) or poly(n-butyl cyanoacrylate) (PBCA) NPs coated with polysorbate 80 (aka Tween 80, T80) in mouse brain (Wilson et al., 2008b)

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