glutathione peroxidase 1 pathway Frontiers Glutathione Peroxidases: An Emerging and

Key mitochondrial and antioxidant molecules such as Cytochrome c, UCH-L1, and thioredoxin domain-containing protein 12 were significantly downregulated

Peroxides generated during the process of metabolism, get eliminated by GPx and GST

The lack of robust clinical evidence limits their use in clinical practice

To address these limitations, future research should prioritize: (1) developing more physiologically relevant preclinical models (e.g., humanized liver chimeras, diet-induced murine models with metabolic comorbidities) to better recapitulate human NAFLD pathophysiology

Independently of its function in the -secretase complex, PSEN1 itself is required for complete lysosomal acidification 108,117,118

Retrieved from : 187 San MartnA.DuP.DikalovaA.LassgueB.AlemanM.GngoraM