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doi: 10.3389/fonc.2026.1748136 Received 18 November 2025 Revised 23 March 2026 Accepted 24 March 2026 Published 30 April 2026 Volume 16 - 2026 Edited by Pierfranco Conte, University of Padua, Italy Reviewed by Valeria Conti, University of Salerno, Italy T Mohan Viswanathan, Karpagam Academy of Higher Education, India Updates Copyright 2026 Talath, El-Tanani, Wali, Rabbani, Bhongande, Ibraheem, Avagimyan, Hoffmann, Ilias, Ispas, Viviana, Paczkowska and Rizzo

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In contrast, global K d-la and K ce levels were largely unresponsive to extracellular glucose concentrations (Fig

Results: HLOs consistently released albumin across 21 days of culture with a slight reduction in the last 7 days

The study concluded that glutathione improves aerobic metabolism and significantly decreases fatigue-related psychological factors, offering a clear mechanistic rationale for its use in energy-limiting chronic illnesses

Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency