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By conducting a cross-sectional analysis of data collected from 1,653 participants, Fu et al

Cost considerations: GLP-1 RAs are generally covered by insurance for diabetes, often not for obesity

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Lipid-regulating drugs also exhibit anti-inflammatory effects by inhibiting MAPK activity and maintaining endothelial cell junctional homeostasis (189)

A significant decrease in adenosine triphosphate (ATP) levels as a result of age and elevated IOP in the optic nerve, as well as a correlation between the rate of axonal dysfunction and the depletion of energy substrates as a result of oxygenglucose deprivation, further implicate metabolism in glaucoma pathogenesis (Baltan et al., 2010)

Beyond glycemic effects, ischemiareperfusion injury is strongly linked to mitochondrial ROS generation at reperfusion (including succinate-associated mechanisms), providing a rationale for exploring perioperative mitochondria-targeted metabolic modulation in IR-prone procedures such as cardiopulmonary bypass (93, 95)